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Terry W. Hill
Professor of Biology
James T. and Valeria B. Robertson Chair in Biological Sciences
Department of Biology
Office: 110 Frazier Jelke West
e-mail hill@rhodes.edu
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BIOL-130
Introductory Biology
BIOL-201 Mycology
BIOL-307 Cell Biology
BCMB-310 Methods in
Biochemistry and Cell Biology
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Research Collaborators
Goals
The long-term goal of research in this laboratory is to understand how the structural components of fungal cell walls are synthesized, assembled according to specific patterns, and developmentally modified throughout the organism's life. Through a better understanding the cell wall we may discover keys to greater control over fungal growth, especially by identifying potential targets of new drugs against infectious fungi.This laboratory is working to identify and characterize genes (Cal genes) in the fungus Aspergillus nidulans, which confer hypersensitivity to the wall-compromising agent Calcofluor White (CFW). This phenotype correlates with defects in wall integrity. Work is underway to carry out extensive phenotypic characterization of several such mutants and to identify specific mutated genes using molecular techniques.
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Students with strong research interests in cell biology, biochemistry, genetics, or microbiology are encouraged to apply for positions in this lab.Click here for
information on undergrad research |
Hill, T. W. and M. P. Pott. 1997. "Regulation of extracellular proteases in Achlya ambisexualis". Canadian Journal of Botany 75: 440-444.
Money, N. P. and T. W. Hill. 1997. "Correlation between endoglucanase secretion and cell wall strength in Oomycete hyphae: Implications for growth and morphogenesis". Mycologia 89: 777-785.
Reichard, U., G. T. Cole, T. W. Hill, R. Rüchel, and M. Monod. 2000. "Molecular characterization and influence on fungal development of ALP2, a novel serine proteinase from Aspergillus fumigatus". International Journal of Medical Microbiology 290: 549-558.
Hill, T. W. and E. Kafer. 2001. "Improved protocols for Aspergillus minimal medium: Trace element and minimal medium salt stock solutions". Fungal Genetics Newsletter 48: 20-21.
Hill, T. W., D. M. Loprete, K. N. Vu, S. P. Bayat Mokhtari, and L. V. Hardin. 2002. "Proteolytic release of membrane-bound endo-(1,4)-b-glucanase activity associated with cell wall softening in Achlya ambisexualis". Canadian Journal of Microbiology 48: 93-98.
Loprete, D. M. and T. W. Hill. 2002. "Isolation and characterization of an endo-(1,4)-b-glucanase secreted by Achlya ambisexualis". Mycologia 94: 903-911.
Hill, T. W., D. M. Loprete, J. A. Castagna, and S. O. Weems. 2003. "Efficient high-volume cleaning of Aspergillus nidulans cleistothecia using bare fingers". Fungal Genetics Newsletter 50: 4-5.
Momany, M., R. Lindsey, T. W. Hill, E. A. Richardson, C. A. Momany, M. Pedreira, G. M. Guest, J. F. Fisher, R. B. Hessler, and K. A. Roberts. 2004. "The Aspergillus fumigatus cell wall is organized in domains that are remodeled during polarity establishment". Microbiology 150: 3261-3268.
Hill, T. W., D. M. Loprete, M. Momany, Y. Ha, L. M. Harsch, J. A. Livesay, A. Mirchandani, J. J. Murdock, M. J. Vaughan, and M. B. Watt. 2006. "Isolation of cell wall mutants in Aspergillus nidulans by screening for hypersensitivity to Calcofluor White". Mycologia 98: 400-410.
Teepe, A. G., D. M. Loprete, Z.-M. He, T. A. Hoggard, and T. W. Hill. 2007. "The protein kinase C orthologue PkcA plays a role in cell wall integrity and polarized growth in Aspergillus nidulans". Fungal Genetics & Biology 44: 554-562.
Jackson-Hayes, L., T. W. Hill, D. M. Loprete, L. M. Fay, B. S. Gordon, S. A. Nkashama, R. K. Patel, and C. V. Sartain. 2008. "Two GDP-mannose transporters contribute to hyphal form and cell wall integrity in Aspergillus nidulans." Microbiology 154: 2037-2047.
